Serotonin is a monoamine neurotransmitter in the CNS and an endogenous5-HT receptoragonist. Serotonin is also acatechol O-methyltransferase(COMT) inhibitor with aK_iof 44 μM.

Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K_i= 44 μM). Results show that addition of 100 μM of Serotonin decreases the reaction velocity of COMT^[1].

Serotonin produces robust hypersensitivity compare to saline-treated controls (p<0.001)^[1]. A significant increase in colonic 5-HT content is observed in IL-13^-/-mice receiving Serotonin compare to IL-13^-/-receiving vehicle following induction of DSS colitis^[2].

176.22

C₁₀H₁₂N₂O

50-67-9

5-羟色胺；血清胺

• Alkaloids
• Indole Alkaloids

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