PNU-282987 free base

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

711085-63-1

PNU-282987 (free base) 是一种有效的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，EC₅₀为 154 nM。 PNU-282987 (free base) 也是 5-HT₃受体的功能性拮抗剂，IC₅₀为 4541 nM。PNU-282987 (free base) 可用于中枢和外周神经系统的研究。

生物活性

PNU-282987 (free base) is a potentα7 nicotinic acetylcholine receptor (nAChR)agonist with anEC₅₀of 154 nM. PNU-282987 (free base) is also a functional antagonist of the5-HT₃receptorwith anIC₅₀of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems^[1].

IC₅₀& Target

5-HT₃Receptor

体外研究
(In Vitro)

PNU-282987 (free base) (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a K_iof 27 nM^[1].
PNU-282987 has α7 nAChR agonist activity with an EC₅₀of 154 nM^[1].
PNU-282987 also has inhibition for the 5-HT₃receptor with an IC₅₀value of 4541nM^[1].

体内研究
(In Vivo)

PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit^[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner^[1].

Animal Model:	Rats^[1]
Dosage:	1, 3 mg/kg
Administration:	i.v.
Result:	Significantly reversed amphetamine-induced gating deficit.

分子量

264.75

Formula

C₁₄H₁₇ClN₂O

CAS 号

711085-63-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.