SB-269970

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SB-269970

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

201038-74-6

SB-269970 是一种有效、选择性和可透过血脑屏障的5-HT7受体拮抗剂，pK_i为 8.3，对 5-HT7 受体选择性大于其他 5-HT 受体。

生物活性

SB-269970 is a potent, selective and brain-penetrant5-HT7 receptorantagonist with apK_iof 8.3. SB-269970 exhibits >50-fold selectivity against other 5-HT receptors^[1]^[2].

IC₅₀& Target

Human 5-HT₇Receptor

8.3 (pKi)

体内研究
(In Vivo)

SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity^[2].

Animal Model:	Male C57BL6/J mice^[2]
Dosage:	3, 10, 30 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly blocked amphetamine and ketamine-induced hyperactivity.

分子量

352.49

Formula

C₁₈H₂₈N₂O₃S

CAS 号

201038-74-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.