Risperidone hydrochloride (R 64 766 hydrochloride)5-HT₂receptorblocker,P-Glycoproteininhibitor and potentdopamineD₂receptorantagonist, withK_isof 4.8, 5.9 nM for 5-HT_2Aand dopamineD₂receptor, respectively.

Risperidone is a serotonin 5-HT₂receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2Aand dopamine D₂receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs^[3].

In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner^[4].

446.95

C₂₃H₂₈ClFN₄O₂

666179-74-4

利哌酮盐酸盐

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.