8-OH-DPAT hydrobromide

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CAS NO:

76135-31-4

8-Hydroxy-DPAT hydrobromide

8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide 是一种有效的，选择性5-HT_1A激动剂，pIC₅₀为 8.19。8-OH-DPAT hydrobromide 对 5-HT₁结合位点的亚型具有近 1000 倍的选择性。

生物活性

8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent and selective5-HT_1Aagonist with apIC₅₀of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT₁binding site^[1].

IC₅₀& Target^[1]

5-HT_1AReceptor

8.19 (pIC₅₀)

体外研究
(In Vitro)

8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide has no effect on 5-HT_1Bbinding at concentrations lower than 100 nM^[1].

体内研究
(In Vivo)

8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide (32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals^[1].

分子量

328.29

性状

Solid

Formula

C₁₆H₂₆BrNO

CAS 号

76135-31-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 25 mg/mL(76.15 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.0461 mL	15.2304 mL	30.4609 mL
5 mM	0.6092 mL	3.0461 mL	6.0922 mL
10 mM	0.3046 mL	1.5230 mL	3.0461 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。