Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor ofserotonin reuptake transporter (SERT)andnoradrenaline reuptake transporter (NET), withK_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds todopamine reuptake transporter (DAT)with aK_iof 2.58 μM. Amitriptyline hydrochloride also inhibitsadrenergic,muscarinic,histamineand5-HT receptors. Amitriptyline hydrochloride is aTrkAandTrkBreceptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity^[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

316.88

C₂₀H₂₁D₃ClN

342611-00-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.