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Sp-Cyclic AMPS(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sp-Cyclic AMPS(sodium salt)图片
CAS NO:142439-95-0
包装与价格：
包装价格(元)
1mg询价
5mg询价

Sp-Cyclic AMPS（钠盐）是一种 cAMP 类似物，是 cAMP 依赖性 PKA I 和 PKA II 的有效激活剂。
Cas No.142439-95-0
别名Sp-cAMPS
化学名cyclic 3',5'-[hydrogen (S)-phosphorothioate] adenosine, monosodium salt
Canonical SMILES[S-][P@]1(OC[C@]2([H])[C@@]([C@@H](O)[C@H](N3C(N=CN=C4N)=C4N=C3)O2)([H])O1)=O.[Na+]
分子式C10H11N5O5PS o Na
分子量367.3
溶解度≤25mg/ml in Water
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sp-8-CPT-Cyclic AMPS (Sp-8-CPT-cAMPS) is a cell permeable cAMP analog that potently and selectively activates protein kinase A [1].

Protein kinase A, also known as cAMP-dependent protein kinase, is one of the most widely researched protein kinase. Protein kinase A phosphorylates proteins containing the motif Arginine-Arginine-X-Serine and activates or deactivates the proteins. Protein kinase A has been involved in regulation of glycogen, sugar, and lipid metabolism [2]. The effects of PKA activation vary with cell type. Protein kinase A has been implicated in muscular system, cardiovascular, and nervous system.

Sp-8-CPT-cAMPS is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs 8-CPT-Cyclic AMP and Sp-Cyclic AMPS. Sp-8-CPT-cAMPS is used to investigate the effects of cAMP-dependent PKA signaling [1]. In guinea-pig trachealis, treatment with 10 μM Sp-8-CPT-cAMPS for 30 min reduced the spasmogenic response with the pEC50 value of 4.74 [3].

References:
[1] Dostmann W R, Taylor S S, Genieser H G, et al.  Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3', 5'-cyclic phosphorothioates[J]. Journal of Biological Chemistry, 1990, 265(18): 10484-10491.
[2] Hanks S K, Quinn A M, Hunter T.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains[J]. Science, 1988, 241(4861): 42-52.
[3] Spicuzza L, Belvisi M G, Birrell M A, et al.  Evidence that the anti‐spasmogenic effect of the β‐adrenoceptor agonist, isoprenaline, on guinea‐pig trachealis is not mediated by cyclic AMP‐dependent protein kinase[J]. British journal of pharmacology, 2001, 133(8): 1201-1212.

 
 
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