TCB2 is an agonist of serotonin5-HT_2Areceptor.

The selective 5-HT_2Aagonist TCB2 at 30 nM produces a marked shift to the right in the competition curve obtained with the 5-HT_1Areceptor agonist ipsapirone from [³H]-8-OHDPAT binding sites in both areas of the brain. A significant increase in the mean K_ivalue is obtained with TCB2, demonstrating a reduction in the affinity of the high-affinity 5-HT_1Aagonist binding sites by the 5-HT_2Aagonist in both regions. In the case of hippocampus, there are also indications for antagonistic effects of ketanserin^[2].

In an initial dose-response study, TCB2 (0.5, 1.0, and 2.5 mg/kg) and DOI (0.5, 1.0, 2.5, and 5.0 mg/kg) induce head twitches in C57BL/6J mice in a dose-dependent manner compared to vehicle. Head twitches induced by TCB2 and DOI are similar across the doses, with the exception that at the highest dose (5.0 mg/kg), TCB2 induces half as many head twitches as does DOI (p=0.021). Confirming 5-HT2A mediation of the head twitch response, in two separate studies, pretreatment with the selective 5-HT_2Aantagonist MDL 11,939 (1.0 mg/kg) block head twitches induced by DOI (2.5 mg/kg) and by TCB2 (2.5 mg/kg; p<0.0001). Compared to vehicle, corticosterone levels are increased following TCB2 (5.0 mg/kg, p=0.01; 10.0, p=0.012; with a trend following 2.5 mg/kg, p=0.079) and DOI (10.0 mg/kg, p=0.035)^[1].

353.05

Solid

C₁₁H₁₅Br₂NO₂

912342-28-0

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 100 mg/mL(283.25 mM;ultrasonic and warming and heat to 60℃)

H₂O : 25 mg/mL(70.81 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。