Peptide 401

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Peptide 401

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

32908-73-9

包装与价格：

包装	价格(元)
500 μg	询价
1mg	询价
5mg	询价

Peptide 401 是一种有效的来源于蜂毒中的肥大细胞脱颗粒肽，抑制血管通透性。

生物活性

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and5-HT).

IC₅₀& Target

serotonin

Histamine Receptor

体内研究
(In Vivo)

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED₅₀of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased¹²⁵I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins)^[1]. Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents^[2].

分子量

2587.22

性状

Solid

Formula

C₁₁₀H₁₉₂N₄₀O₂₄S₄

CAS 号

32908-73-9

Sequence

Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

Sequence Shortening

IKCNCKRHVIKPHICRKICGKN-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(19.33 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.3865 mL	1.9326 mL	3.8652 mL
5 mM	0.0773 mL	0.3865 mL	0.7730 mL
10 mM	0.0387 mL	0.1933 mL	0.3865 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。