SB228357

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SB228357

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

181629-93-6

SB228357 是一种选择性的，有效的具有口服活性的5-HT_2C/2B受体拮抗剂，其对5-HT_2A，5-HT_2B和5-HT_2C的pK_i值分别为 6.9、8.0 和 9.0。SB228357 具有抗抑郁/抗焦虑作用。

生物活性

SB228357 is a selective, potent and orall active5-HT_2C/2Breceptorantagonist withpK_ivalues of 6.9, 8.0 and 9.0 for5-HT_2A,5-HT_2Band5-HT_2C, respectively. SB228357 has antidepressant/anxiolytic effects^[1]^[2].

IC₅₀& Target^[1]

5-HT_2AReceptor

6.9 (pKi)

5-HT_2CReceptor

9 (pKi)

5-HT_2BReceptor

8 (pKi)

体内研究
(In Vivo)

SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy^[2].

Animal Model:	Male Sprague Dawley rats (200-250 g) injected with Haloperidol^[2]
Dosage:	0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg
Administration:	Oral administration; for 90 minutes
Result:	Significantly reversed Haloperidol-induced catalepsy.

分子量

431.38

性状

Solid

Formula

C₂₂H₁₇F₄N₃O₂

CAS 号

181629-93-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month