cis-(Z)-Flupentixol dihydrochloride

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CAS NO:

51529-01-2

盐酸氟哌噻吨
cis-(Z)-Flupenthixol dihydrochloride

cis-(Z)-Flupentixol dihydrochloride 是有效、选择性的多巴胺DA D1/D2受体的拮抗剂，其对D2 受体和5-HT_2A的K_i值分别为 0.38 nM 和 7 nM。

生物活性

cis-(Z)-Flupentixol dihydrochloride is a potent and selectiveDA D1/D2 receptorantagonist, withK_ivalues of 0.38 nM and 7 nM for D2 receptor and5-HT_2A, respectively^[1]^[2].

IC₅₀& Target^[2]

D₂Receptor

0.38 nM (Ki)

5-HT_2AReceptor

7 nM (Ki)

体内研究
(In Vivo)

cis-(Z)-Flupentixol (0.25, or 0.5 mg/kg, i.p.) pretreatment dose-dependently reduces cocaine-induced activity^[1].

Animal Model:	Rats^[1].
Dosage:	0.125, 0.25, or 0.5 mg/kg.
Administration:	IP.
Result:	Reduced cocaine-induced activity.

分子量

507.44

Formula

C₂₃H₂₇Cl₂F₃N₂OS

CAS 号

51529-01-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL(123.17 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9707 mL	9.8534 mL	19.7068 mL
5 mM	0.3941 mL	1.9707 mL	3.9414 mL
10 mM	0.1971 mL	0.9853 mL	1.9707 mL