R 568 hydrochloride (R 568 Hydrochloride) 是一种具有口服活性的拟钙化合物，可通过变构正向调节钙敏感受体 (CaSR)。
| Cas No. | 177172-49-5 |
| 别名 | 2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐,R-568 hydrochloride |
| 化学名 | (R)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride |
| Canonical SMILES | ClC1=CC=CC=C1CCCN[C@H](C)C2=CC=CC(OC)=C2.Cl |
| 分子式 | C18H22ClNO.HCl |
| 分子量 | 340.29 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3]. References:
[1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997).
[2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996).
[3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998). |
