LE 300 是一种有效的选择性多巴胺 D1 样受体拮抗剂，在表达人多巴胺 D1 和 D5 受体的 CHO 细胞膜中，其Kis 分别为 1.9 nM 和 7.5 nM。在一项大鼠尾动脉实验中，LE 300 是5-HT2A受体的拮抗剂，pA2 为 8.32。
| 生物活性 | LE 300 is a potent and selectivedopamine D1-like receptorantagonist withKis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2Areceptor with a pA2 of 8.32 in a rat tail artery assay[1][2]. |
| IC50& Target | Human D1Receptor 1.9 nM (Ki) | Human D5Receptor 7.5 nM (Ki) | Rat 5-HT2A 8.32 (pA2) |
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
