BRL-15572 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1173022-77-9

BRL-15572 hydrochloride 是h5-HT1D的选择性拮抗剂，对h5-HT1D受体显示出高亲和力。 BRL-15572 hydrochloride 可能是表征h5-HT1D受体介导的反应的有用药理剂。

生物活性

BRL-15572 hydrochloride is a selective antagonist ofh5-HT1D, displays high affinity forh5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise5-HT1D receptormediated responses^[1].

IC₅₀& Target^[1]

5-HT_1DReceptor

体外研究
(In Vitro)

BRL-15572 has 60-fold higher affinity for h5-HT1D (pK_i=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells^[1].
BRL-15572 (0.1 nM-10 μM) stimulates [³⁵S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors^[1].

体内研究
(In Vivo)

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test^[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig^[3].

分子量

443.41

Formula

C₂₅H₂₈Cl₂N₂O

CAS 号

1173022-77-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.