BGC20-761

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BGC20-761

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

17375-63-2

BGC20-761 是一种选择性的5-HT6和多巴胺受体 (dopamine receptor) 拮抗剂，对人 5-HT6，5-HT2A，D2 受体的K_i值分别为 20，69，和 140 nM。BGC20-761 可增强长期记忆。BGC20-761 可用于抗精神病的研究。

生物活性

BGC20-761 is a selecvtive5-HT6anddopamine receptorantagonist (human receptorK_ivalues: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent^[1].

IC₅₀& Target^[1]

Human 5-HT₆Receptor

20 nM (Ki)

Human 5-HT_2AReceptor

69 nM (Ki)

Human D₂Receptor

140 nM (Ki)

体外研究
(In Vitro)

BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat K_ivalues for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM)^[1].

体内研究
(In Vivo)

BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.)^[1].

Animal Model:	Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats^[1]
Dosage:	2.5 mg/kg, 5 mg/kg and 10 mg/kg
Administration:	Administered (i.p.) immediately after the training session for the social recognition test
Result:	Administered alone did not show any difference in social recognition as compared to saline treated control animals. However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition.

分子量

294.39

Formula

C₁₉H₂₂N₂O

CAS 号

17375-63-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.