SB-221284

立即咨询

SB-221284

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

196965-14-7

SB 221284 是一种选择性5-HT_2C/2B受体拮抗剂，5-HT_2A,5-HT_2B和5-HT_2C受体的pK_i值分别为 6.4, 7.9 和 8.6。SB 221284可用于神经系统疾病的研究.

生物活性

SB 221284 is a selective5-HT_2C/2Breceptor antagonist withpK_ivalues are 6.4, 7.9 and 8.6 for5-HT_2A,5-HT_2Band5-HT_2Creceptors, respectively. SB 221284 can be used for the research ofneurological disease^[1].

IC₅₀& Target^[1]

5-HT_2AReceptor

6.4 (pKi)

5-HT_2BReceptor

7.9 (pKi)

5-HT_2CReceptor

8.6 (pKi)

体内研究
(In Vivo)

SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801^[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine^[1]

Animal Model:	Male Sprague Dawley rats (250–360 g)^[1]
Dosage:	0.1~1 mg/kg
Administration:	I.p.
Result:	Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.

Animal Model:	Male Sprague Dawley rats (250–360 g)^[1]
Dosage:	1 mg/kg
Administration:	I.p.
Result:	Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.

分子量

353.36

Formula

C₁₆H₁₄F₃N₃OS

CAS 号

196965-14-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.