Masupirdine free base

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

701205-60-9

SUVN-502 free base

Masupirdine free base (SUVN-502 free base) 是一种有效的，选择性的，具有口服生物可利用且可穿透脑屏障的5-HT6受体拮抗剂 (对人 5-HT6 受体的K_i为 2.04 nM)。Masupirdine free base (SUVN-502 free base) 对 5-HT2A 受体和其他 100个靶点显示高选择性，有研究阿尔茨海默病的潜力。

生物活性

Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant5-HT6 receptorantagonist (K_iof 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease^[1].

IC₅₀& Target^[1]

5-HT₆Receptor

2.04 nM (Ki)

Clinical Trial

分子量

478.40

Formula

C₂₁H₂₄BrN₃O₃S

CAS 号

701205-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.