WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic5-HT_1Areceptor, with anIC₅₀of 34 nM at the rat hippocampal 5-HT_1Areceptor. WAY-100135 dihydrochloride has potential antipsychotic properties^[1][2].

WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA₂of 7.2^[1].
WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons^[2].

WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats^[1].
WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats^[2].

468.46

C₂₄H₃₅Cl₂N₃O₂

149055-79-8

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