PF-4479745

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PF-4479745

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1065110-43-1

PF-4479745 是一种有效的5-HT_2C受体选择性激动剂 (EC₅₀: 10 nM,k_i: 15 nM)。PF-4479745 可用于高血压等心血管疾病的研究。

生物活性

PF-4479745 is a potent and selective5-HT_2Creceptor agonist (EC₅₀: 10 nM,k_i: 15 nM). PF-4479745 can be used in the research ofcardiovascular diseaselike hypertension^[1].

IC₅₀& Target^[1]

5-HT_2CReceptor

10 nM (EC₅₀)

5-HT_2CReceptor

15 nM (Ki)

5-HT_2AReceptor

360 nM (IC₅₀)

5-HT_2BReceptor

67 nM (IC₅₀)

5-HT_1AReceptor

500 nM (IC₅₀)

5-HT₆Receptor

280 nM (IC₅₀)

体外研究
(In Vitro)

PF-4479745 (copmpound 17) exhibits metabolic stability in both human liver microsomes (HLM) and human hepatocytes^[1].

体内研究
(In Vivo)

PF-4479745 (compound 17, intravenous injection) shows high clearance rate (104 mL/min/kg)^[1].
PF-4479745 demonstrates a robust dose-dependent effect in canine PUP (peak urethral pressure) model of SUI (stress urinary incontinence)^[1].

分子量

282.38

Formula

C₁₇H₂₂N₄

CAS 号

1065110-43-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.