Pardoprunox (SLV-308) is a partialdopamine D2andD3 receptorpartial agonist and aserotonin 5-HT1A receptoragonist, withpEC₅₀s of 8, 9.2, and 6.3, respectively^[1].

Pardoprunox (SLV-308) acts as a potent but partial D2 receptor agonist (pEC₅₀= 8.0 and pA₂=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC₅₀=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA₂=9.0). Pardoprunox acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC₅₀=6.3)^[1].

233.27

C₁₂H₁₅N₃O₂

269718-84-5

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