Angiopeptin TFA

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Angiopeptin TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2478421-60-0

血管抑肽三氟乙酸盐

Angiopeptin TFA 是生长抑素的环状八肽类似物，是一种sst₂/sst₅受体部分激动剂，IC₅₀值分别为 0.26 nM 和 6.92 nM。Angiopeptin TFA 可以抑制生长激素释放和胰岛素样生长因子-1 (IGF-1) 产生。Angiopeptin TFA 抑制腺苷酸环化酶或刺激细胞外酸化。Angiopeptin TFA 具有用于冠状动脉粥样硬化研究的潜力。

生物活性

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weaksst₂/sst₅receptor partial agonist withIC₅₀values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release andinsulin-like growth factor-1 (IGF-1)production. Angiopeptin TFA inhibitsadenylate cyclaseor stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research^[1]^[2].

IC₅₀& Target

IC50: 0.26 nM (sst2) and 6.92 nM (sst5)^[1]^[2]

体外研究
(In Vitro)

Angiopeptin (0.1 nM- 10 μM; for 1 h) TFA acts as a partial agonist (pEC₅₀=6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst₂cells^[2].

体内研究
(In Vivo)

Angiopeptin (20 and 50μg/kg; i.h.) TFA significantly inhibits neointimal formation^[1].
Angiopeptin (20 μg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%^[1].

分子量

1326.39

性状

Solid

Formula

C₅₈H₇₃F₆N₁₁O₁₄S₂

CAS 号

2478421-60-0

Sequence Shortening

{Nal}CYWKVCT-NH2

中文名称

血管抑肽三氟乙酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 10 mg/mL(7.54 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.7539 mL	3.7696 mL	7.5393 mL
5 mM	0.1508 mL	0.7539 mL	1.5079 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。