AC1-IN-1

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AC1-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2762422-55-7

AC1-IN-1 是一种有效的选择性AC1抑制剂，其IC₅₀为 0.54 μM. AC1-IN-1 在炎症性疼痛小鼠模型中表现出适度的抗异常疼痛的作用。AC1-IN-1 具有 CNS 活性。

生物活性

AC1-IN-1 is a potent and selectiveAdenylyl cyclase type 1 (AC1)inhibitor with anIC₅₀of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity^[1].

IC₅₀& Target

IC₅₀: 0.54 μM (AC1)^[1]

体外研究
(In Vitro)

AC1-IN-1 (compound 38; HEK293 cells; 30 μM, 1 hours) shows nontoxic to this human cell line^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	HEK293 cells
Concentration:	30 μM
Incubation Time:	1 hours
Result:	Showed nontoxic to HEK293 cells.

体内研究
(In Vivo)

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point^[1].

Animal Model:	Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)^[1]
Dosage:	5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration:	Intravenous injection; 2 hours
Result:	Displayed modest, yet statistically significant, antiallodynic effects.

分子量

355.37

性状

Solid

Formula

C₁₈H₁₈FN₅O₂

CAS 号

2762422-55-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 25 mg/mL(70.35 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8140 mL	14.0698 mL	28.1397 mL
5 mM	0.5628 mL	2.8140 mL	5.6279 mL
10 mM	0.2814 mL	1.4070 mL	2.8140 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。