LY377604 is ahuman β₃-adrenergic receptoragonist with anEC₅₀of 2.4 nM and also aβ₁- andβ₂-adrenergic receptorantagonist.

EC50: 2.4 nM (human β₃-adrenergic receptor)^[1]
β₁-adrenergic receptor, β₂-adrenergic receptor^[1]

LY377604 is a human β₃-adrenergic receptor agonist with an EC₅₀of 2.4 nM and also a β₁- and β₂-adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β₁adrenergic receptor or the human β₂adrenergic receptor^[1].

Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats^[1].

524.61

C₃₁H₃₂N₄O₄

204592-94-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.