Norepinephrine (Levarterenol; L-Noradrenaline) tartrate 是一种有效的肾上腺素能受体 (AR) 激动剂。Norepinephrine tartrate 可以激活 α1、α2、β1受体。
| 生物活性 | Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potentadrenergic receptor(AR)agonist. Norepinephrine tartrate activates α1, α2, β1receptors[1][2][3][4]. |
| IC50& Target[1] | α1-adrenergic receptor | α2-adrenergic receptor | Beta-1 adrenergic receptor | Microbial Metabolite | Human Endogenous Metabolite |
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体外研究
(In Vitro) | Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations[2].
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[3].
RT-PCR[2] | Cell Line: | Subcutaneous preadipocytes Adipocytes. | | Concentration: | 10 μM. | | Incubation Time: | 6 hours. | | Result: | AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
