Carvedilol phosphate hemihydrate

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CAS NO:

610309-89-2

BM 14190 phosphate hemihydrate

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种非选择性β/α-1受体阻断剂。Carvedilol 抑制脂质过氧化，IC₅₀为 5 μM。Carvedilol 是一种多用途降压剂，有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂，可抑制 NLRP3 炎性体。

生物活性

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selectiveβ/α-1blocker^[1]. Carvedilol phosphate hemihydrate inhibitslipid peroxidationwith an IC₅₀of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol phosphate hemihydrate is anautophagyinducer that inhibits theNLRP3inflammasome^[3].

IC₅₀& Target

β/α-1 adrenergic receptor^[1]
IC50: 5 μM (lipid peroxidation)^[2]
Autophagy^[3]

体外研究
(In Vitro)

Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC₅₀of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC₅₀of 25 μM^[2].

Clinical Trial

分子量

513.48

Formula

C₂₄H₂₆N₂O₄. H₃PO₄.1/2H₂O

CAS 号

610309-89-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.