Adrenaline sulfate 是一种由肾上腺髓质分泌的口服活性激素。Adrenaline sulfate 是一种 α-adrenergic 和 β-adrenergic 受体激动剂。Adrenaline sulfate 可用于治疗过敏反应。Adrenaline sulfate 具有心脏骤停研究潜力[4]。
| 生物活性 | Adrenaline sulfate is a orally active hormone secreted by the medulla of the adrenal glands. Adrenaline sulfate is anα-adrenergicandβ-adrenergicreceptor agonist. Adrenaline sulfate can be used in the treatment of anaphylaxis. Adrenaline sulfate has the potential for the research of cardiac arrest[1][2][3][4]. |
| IC50& Target | Human Endogenous Metabolite |
|
体内研究
(In Vivo) | Adrenaline sulfate (0.75, 1.5, 3 mg/kg; i.p.) exerts oxidative and nitrative stress in rats, increased damage to lipids and proteins, and damage of cardiomyocytes and cytogenetic damage in rats[2].
Adrenaline sulfate (0.02, 0.03 mg/kg) increases ABP’s and to some extent also CePP, but significantly decreases organ and brain perfusion in adult pigs[3].
Adrenaline sulfate (0.1 mg/kg; s.c.) enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory[6].
| Animal Model: | 220-280 g, 18 weeks Wistar rats[2] | | Dosage: | 0.75, 1.5, 3 mg/kg | | Administration: | IP | | Result: | Induced a significant rise in CAT activity, MDA level, PCC, NO2–, and 3-NT and a significant decrease in SOD activity, and exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes. |
| Animal Model: | 24-25 month male Fischer-344 rats[6] | | Dosage: | 0.1 mg/kg | | Administration: | S.c. | | Result: | Enhanced memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory. |
|
| Clinical Trial | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
