1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

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CAS NO:

120693-53-0

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone，一种喹诺酮类生物碱，是二酰基甘油酰基转移酶抑制剂和血管紧张素 II 受体阻断剂，IC₅₀值分别为 20.1 μM 和 34.1 μM。1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 显示出有效的抗幽门螺杆菌活性，MIC 值为 10 μg/mL。

生物活性	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, aquinolonealkaloid, is adiacylglycerolacyltransferaseinhibitor andangiotensin II receptorblocker, withIC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pyloriactivity with the MIC of 10 μg/mL^[1]^[2]^[3].
IC₅₀& Target	IC50: 20.1 μM (diacylglycerol acyltransferase)^[3], 34.1 μM (angiotensin II receptor)^[2]
体外研究 (In Vitro)	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows anti-Helicobacter pylori activity, with the MIC of 10 μg/mL, and has no effect on Helicobacter pylori urease activity at the concentration of 300 μg/mL^[1]. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-500 μM) shows a dose-dependent diacylglycerol acyltransferase (DGAT) inhibition, with an IC₅₀of 20.1 μM^[3]. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-20 μM) inhibits leukotriene biosynthesis in human polymorphonuclear granulocytes, with an IC₅₀of 10.1 μM^[4].
分子量	337.50
Formula	C₂₃H₃₁NO
CAS 号	120693-53-0
结构分类	Alkaloids Quinoline Alkaloids
来源	Plants Rutaceae Evodia rutaecarpa(Juss.) Benth.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.