GSK1820795A

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GSK1820795A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2650253-86-2

GSK1820795A 作为替米沙坦类似物是hGPR132a的选择性拮抗剂。GSK1820795A阻断了 N-acylamides 对表达hGPR132a的酵母细胞的活化。GSK1820795A也是血管紧张素 II拮抗剂和部分PPARγ激动剂 (compound 38) 。

生物活性

GSK1820795A, as a telmisartan analog, is a selectivehGPR132aantagonist. GSK1820795A blocks activation of yeast cells expressinghGPR132aby N-acylamides^[1]. GSK1820795A is also aangiotensin II antagonistsand partialPPARγagonists (compound 38)^[2].

IC₅₀& Target

AT1 Receptor

0.006 μM (IC₅₀)

hPPARγ

0.25 μM (EC₅₀)

mouse PPARγ

0.27 μM (EC₅₀)

体外研究
(In Vitro)

GSK1820795A blocks responses of yeast expressing hGPR132a to agonists NPGly, NLGly, linoleamide, and SB-583831^[1].

分子量

566.70

Formula

C₃₅H₃₄N₈

CAS 号

2650253-86-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.