CB1/2 agonist 3

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CB1/2 agonist 3

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CAS NO:

2772655-86-2

CB1/2 agonist 3 (compound 52) 是一种CB1/CB2(cannabinoid receptor) 竞争性激动剂，有效的非选择性大麻素配体。CB1/2 agonist 3 作用于 hCB1 和 hCB2 的 K_i值分别为 5.9 nM 和 3.5 nM。

生物活性

CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is aCB1/CB2(cannabinoid receptor) competitive agonist. CB1/2 agonist 3 acts on hCB1 and hCB2 with K_ivalues of 5.9 nM and 3.5 nM, respectively^[1].

IC₅₀& Target^[1]

hCB1-R

5.9 nM (Ki)

hCB2-R

3.5 nM (Ki)

体外研究
(In Vitro)

CB1/2 agonist 3 (compound 52) can partially induce [³⁵S]GTPγS binding to hCB1-CHO cell membranes with an EC₅₀value of 30.99 nM, and slightly inhibit [³⁵S]GTPγS binding to hCB2-CHO cell membranes with a mean EC₅₀value of 1.28 nM^[1].
CB1/2 agonist 3 (compound 52) ((1 μM, 1 h) has antagonistic effect on CB1/CB2 agonist CP-55940 with a K_bvalue of 78.17 nM^[1].

分子量

387.60

Formula

C₂₅H₄₁NO₂

CAS 号

2772655-86-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.