Ebselen oxide 是 Ebselen 的硒酮类似物，共价修饰二鸟苷酸环化酶 (DGC) 以抑制 c-di-GMP-受体相互作用并降低 DGC 活性。
| Cas No. | 104473-83-8 |
| 别名 | NSC 639772 |
| 化学名 | 1-oxide-2-phenyl-1,2-benzisoselenazol-3(2H)-one |
| Canonical SMILES | O=[Se](N1C2=CC=CC=C2)C3=CC=CC=C3C1=O |
| 分子式 | C13H9NO2Se |
| 分子量 | 290.2 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): .15 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ebselen is an excellent scavenger of peroxynitrite and is used for the treatment of cerebral infarctions. Ebselen oxide, formed by the oxidation of ebselen, lacks antioxidant activity, indicating that it can serve as a negative control for ebselen.[1] Reference:
[1]. Lass, A., Witting, P., Stocker, R., et al. Inhibition of copper- and peroxyl radical-induced LDL lipid oxidation by ebselen: Antioxidant actions in addition to hydroperoxide-reducing activity. Biochimica et Biophysica Acta 1303, 111-118 (1996). |
