MRL-650

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MRL-650

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

852315-00-5

CB1 inverse agonist 1

MRL-650 (CB1 inverse agonist 1) 是一种高效的，具有口服活性的，特异性CB1受体的反向激动剂，对CB1和CB2受体的IC₅₀分别为 7.5 nM 和 4100 nM。具有抑制食欲作用。

生物活性

MRL-650 (CB1 inverse agonist 1) is a highly potent, orally active, and specific inverse agonist ofCB1receptorwithIC₅₀s of 7.5 nM and 4100 nM forCB1andCB2receptors, respectively. Anorexigenic effects^[1].

IC₅₀& Target^[1]

CB1

7.5 nM (IC₅₀)

CB2

4100 nM (IC₅₀)

体内研究
(In Vivo)

MRL-650 (Compound 14; 0.3, 1, or 3 mg/kg）inhibits feeding in a dose-dependent manner^[1].
The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t_1/2of >8, >8, >24, and 22 h, respectively^[1].

Animal Model:	Rat^[1]
Dosage:	0.3, 1, or 3 mg/kg
Administration:	PO
Result:	Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels.

分子量

514.79

Formula

C₂₅H₁₈Cl₃N₃O₃

CAS 号

852315-00-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.