CB2R PAM

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CB2R PAM

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2244579-87-9

CB2R PAM 是一种具有口服活性大麻素 2 型受体(CB2Rs)正向变构调节剂。CB2R PAM 在神经病理性疼痛小鼠模型中显示抗伤害活性。

生物活性

CB2R PAM is an orally activecannabinoid type-2 receptors (CB2Rs)positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain^[1].

IC₅₀& Target

cannabinoid type-2 receptors

体外研究
(In Vitro)

CB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs^[1].

体内研究
(In Vivo)

CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity^[1].

Animal Model:	Male CD-1 albino mice (Oxaliplatin-induced neuropathic pain model)^[1]
Dosage:	1, 5, 10, 20 mg/kg
Administration:	P.o.
Result:	Significantly increased licking latency in the animals starting from 5 mg/kg.

分子量

435.33

Formula

C₂₁H₂₄BrFN₂O₂

CAS 号

2244579-87-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.