L759633

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L759633

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

174627-50-0

L759633 是一种有效和选择性的大麻素受体 2CB₂受体激动剂，对 CB2 和 CB1 的K_i值分别为 6.4 nM 和 1043 nM。L759633 可以抑制 Forskolin 刺激的 cAMP 产生。

生物活性

L759633 is a potent and selective agonist ofcannabinoid receptor(CB₂)receptor, withK_is of 6.4 nM and 1043 nM forCB2andCB1receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production^[1]^[2].

IC₅₀& Target

CB2

6.4 nM (Ki)

CB1

1043 nM (Ki)

体外研究
(In Vitro)

L759633 (0.1-1000 nM) inhibits Forskolin-stimulated cyclic AMP production in CB2-transfected cells, with an EC₅₀of 8.1 nM^[1].
L759633 inhibits Forskolin-stimulated cyclic AMP production by 48% at the concentration of 10 μM^[1].

分子量

384.59

Formula

C₂₆H₄₀O₂

CAS 号

174627-50-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.