BMS-817399

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BMS-817399

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1202400-18-7

BMS-817399 是一种强效、选择性、口服生物利用度CCR1拮抗剂。BMS-817399 的 CCR1 结合亲和力和趋化抑制能力分别为 1 和 6 nM (IC₅₀)。BMS-817399 可用于类风湿性关节炎的研究。

生物活性

BMS-817399 is a potent, selective, and orally bioavailableCCR1antagonist. BMS-817399 exhibitsCCR1binding affinity and chemotaxis inhibition potencies of 1 and 6 nM (IC₅₀), respectively. BMS-817399 can be used for the research of rheumatoid arthritis^[1].

IC₅₀& Target^[1]

CCR1

1 nM (IC₅₀)

体外研究
(In Vitro)

In addition to MIP-1α (CCL3), BMS-817399 potently inhibits chemotaxis induced by other CCR1 ligands^[1].

Clinical Trial

分子量

454.00

Formula

C₂₃H₃₆ClN₃O₄

CAS 号

1202400-18-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.