LY288513

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LY288513

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

147523-65-7

LY288513，一种选择性非肽CCK-B受体拮抗剂，其 IC₅₀值为 16 nM。LY288513 在小鼠体内产生抗焦虑作用。

生物活性

LY288513 is a selective non-peptideCCK-Breceptor antagonist with an IC₅₀value of 16 nM. LY288513 produces an anxiolytic-like action in mice^[1]^[2]^[3].

IC₅₀& Target

IC50: 16 nM (CCK-B receptor)^[1]

体外研究
(In Vitro)

LY288513 (10 nM; 2 days) suppresses the effects of CCK-8 on CD4⁺T cell subset-specific transcription factors^[2].

RT-PCR^[2]

Cell Line:	CD4⁺T cells
Concentration:	10 nM
Incubation Time:	2 days
Result:	Suppressed the effects of CCK-8 on CD4⁺T cell subset-specific transcription factors.

体内研究
(In Vivo)

LY288513 (3, 10 mg/kg, i.p.; 10, 30 mg/kg, p.o.) produces an anxiolytic-like action in mice^[3].
LY288513 (1000 mg/kg, p.o.) potentiates the effects of a CNS depressant, slightly lowered body temperature, and had modest sedative effects only at the highest dose examined^[3].

Animal Model:	Male CD-l mice^[3]
Dosage:	3, 10 mg/kg; 10, 30 mg/kg
Administration:	I.p.; p.o.
Result:	Displayed anxiolytic-like effects in the elevated plusmaze.

分子量

436.30

Formula

C₂₂H₁₈BrN₃O₂

CAS 号

147523-65-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.