Anthramycin 是一种有效的抗生素 (antibiotic)，属于苯并二氮杂卓 (PBD) 家族。Anthramycin 具有强大的抗肿瘤 (antitumor) 活性。在小鼠中枢神经系统中，Anthramycin 可作为胆收缩素 (cholecystokinin) 的有效拮抗剂。
| 生物活性 | Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potentantibiotic. Anthramycin has potentantitumoractivity. Anthramycin can act as an potent antagonist ofcholecystokininin the central nervous system in mice[1][2][3]. |
体外研究
(In Vitro) | ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC[1].
Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria[3].
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体内研究
(In Vivo) | Anthramycin (0-0.5 mg/kg, IP, once) has potent anti-CCK (cholecystokinin) activity and antinociceptive effects in the central nervous system in mice[2].
Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart[3].
| Animal Model: | Male ddY mice (20 ± 2 g, 12-14 each group)[2] | | Dosage: | 0, 0.3, and 0.5 mg/kg | | Administration: | IP, once, 10 min before the intracisternal (i.c.) injection of CCK | | Result: | Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg). |
| Animal Model: | Female CFN Gif rats (140-180 g)[3] | | Dosage: | 0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg | | Administration: | SC, daily for 8 days | | Result: | Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
