Gastrazole

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Gastrazole

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

862583-15-1

JB95008

Gastrazole (JB95008) 是一种有效的和选择性的CCK2/gastrin受体拮抗剂。Gastrazole 可降低胃酸水平。Gastrazole 抑制胃泌素刺激的胰腺癌生长。

生物活性

Gastrazole (JB95008) is potent and selective CCK2/gastrin receptor antagonist. Gastrazole can decrease the level of gastric acid. Gastrazole inhibits the Gastrin-stimulated growth of pancreaticcancer^[1]^[2].

IC₅₀& Target

CCK2/gastrin receptor^[1]

体内研究
(In Vivo)

Gastrazole (0.15-3 μmol/kg; i.v.) dose-dependently inhibits the Pentagastrin-stimulated gastric acid secretion^[2].

Animal Model:	Male Sprague-Dawley rats with a gastric fistula^[2]
Dosage:	0.15, 0.3, 3 mg/kg
Administration:	Intravenous administration
Result:	Dose-dependently inhibited Pentagastrin-stimulation acid secretion by maximally 73%.

分子量

687.63

Formula

C₃₄H₃₂FN₅Na₂O₇

CAS 号

862583-15-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.