a-Helical Corticotropin Releasing Factor(12-41)

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CAS NO:

158535-55-8

a-Helical Corticotropin Releasing Factor (12-41) 是一种 30 个氨基酸长度的，促肾上腺皮质激素释放因子/激素的 α 螺旋类似物。促肾上腺皮质激素释放因子 (CRF) 是一种下丘脑激素，能刺激肾上腺皮质激素 (ACTH) 的分泌。a-Helical Corticotropin Releasing Factor (12-41) 则会抑制这种刺激作用。

生物活性

a-Helical Corticotropin Releasing Factor (12-41) is a 30amino acidslong, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect^[1]^[2].

体外研究
(In Vitro)

a-Helical Corticotropin Releasing Factor (0.3 nM; 5-min pulses every 40 min alternately) shows the inhibitory effect on stimulated release of immunoreactive ACTH from perifused equine anterior pituitary cells in vitro.^[2].
a-Helical Corticotropin Releasing Factor (0.5-5 μM) suppresses CRH-induced ACTH secretion^[2].

体内研究
(In Vivo)

a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings^[1].

Animal Model:	Guinea pig pups (20-26 days old and )^[1]
Dosage:	15, 50, 150 μg per animal
Administration:	Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min.
Result:	Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups. Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity.

分子量

3497.01

Formula

C₁₅₂H₂₅₁N₄₃O₄₇S₂

CAS 号

158535-55-8

Sequence Shortening

FHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.