AZD8309

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AZD8309

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

333742-48-6

AZD8309 是一种口服有效的CXCR2拮抗剂。AZD8309 能够调节中性粒细胞的转运，能够用于炎症系列疾病的研究。

生物活性

AZD8309 is an orally active antagonist ofCXCR2. AZD8309 has the ability to regulate the transmigration of neutrophils. AZD8309 can be used in the study of inflammatory diseases^[1].

IC₅₀& Target^[1]

CXCR2

体内研究
(In Vivo)

AZD8309 (50 mg/kg; 口服给药; 每天 2 次) 降低小鼠实验性胰腺炎中性粒细胞迁移和胰腺蛋白酶激活^[1]。

Animal Model:	Male C57BL6 mice (25-30 g) with experimental pancreatitis^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage; twice daily starting 3 h prior to pancreatitis induction
Result:	Significantly reduced MPO in the pancreas and lungs (8 h & 24 h) and reduced intrapancreatic trypsin and elastase activity (8 h) in caerulein-pancreatitis. Reduced serum cytokine levels as well as histopathological damage.

分子量

384.42

Formula

C₁₅H₁₄F₂N₄O₂S₂

CAS 号

333742-48-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.