CXCR4 antagonist 6

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CXCR4 antagonist 6

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2304750-68-1

CXCR4 antagonist 6 (compound 46) 是一种有效的CXCR4拮抗剂，IC₅₀为 79 nM。CXCR4 antagonist 6 可抑制 CXCL12 诱导的胞质钙离子流量 (IC₅₀= 0.25 nM)。CXCR4 antagonist 6 显著减弱 CXCL12/CXCR4 介导的细胞迁移。CXCR4 antagonist 6 在小鼠肿瘤转移模型中显示出显著的抗肿瘤效果。

生物活性

CXCR4 antagonist6 (compound 46) is a potentCXCR4antagonist with anIC₅₀value of 79 nM.CXCR4 antagonist6 inhibits CXCL12 induced cytosolic calcium flux (IC₅₀= 0.25 nM).CXCR4 antagonist6 significantly mitigates CXCL12/CXCR4 mediated cell migration.CXCR4 antagonist6 exhibits marked efficacy in acancermetastasis model in mice^[1].

IC₅₀& Target^[1]

CXCR4

79 nM (IC₅₀)

分子量

366.50

Formula

C₂₁H₃₀N₆

CAS 号

2304750-68-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.