CXCR4 antagonist 5

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CXCR4 antagonist 5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2304749-86-6

CXCR4 antagonist 5 (compound 23) 是一种高效的CXCR4拮抗剂，IC₅₀为 8.8 nM。CXCR4 antagonist 5 可抑制 CXCL12 诱导的胞质钙离子增加 (IC₅₀= 0.02 nM)，也能抑制 CXCR4/CXLC12 介导的趋化作用。CXCR4 antagonist 5 具有良好的理化性质和体外安全性，轻度或中度抑制 CYP 同工酶和 hERG。

生物活性

CXCR4 antagonist5 (compound 23) is a highly potentCXCR4antagonist with anIC₅₀value of 8.8 nM.CXCR4 antagonist5 can inhibit CXCL12-induced cytosolic calcium increase (IC₅₀= 0.02 nM) and inhibits CXCR4/CXLC12-mediated chemotaxis.CXCR4 antagonist5 has good physicochemical properties andin vitrosafety profiles, inhibiting CYP isozymes and hERG marginally or moderately^[1].

IC₅₀& Target^[1]

CXCR4

8.8 nM (IC₅₀)

分子量

366.50

Formula

C₂₁H₃₀N₆

CAS 号

2304749-86-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.