TLQP-21

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TLQP-21

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

869988-94-3

TLQP-21 是 VGF 衍生的具有内分泌和内分泌特性的肽，是一种强效的 G 蛋白偶联受体补体 3a 受体 1 (C3aR1) 激动剂 (EC₅₀：小鼠 TLQP-21=10.3 μM；人 TLQP-21=68.8 μM)。TLQP-21 激活 C3aR1，从而诱导细胞内 Ca²⁺的增加。TLQP-21 可用于研究调节伤害感受和其他相关生理功能。

生物活性

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potentG-protein-coupled receptor complement-3a receptor 1 (C3aR1)agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions^[1]^[2].

体外研究
(In Vitro)

TLQP-21 is a peptide of 21 amino acids. At a dose of 3 μM TLQP-21 induces up to ~69% of the corresponding contraction promoted by acetylcholine^[1]^[2].

分子量

2432.75

Formula

C₁₀₇H₁₇₀N₄₀O₂₆

CAS 号

869988-94-3

Sequence

Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg

Sequence Shortening

TLQPPASSRRRHFHHALPPAR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.