Lornoxicam

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Lornoxicam

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

70374-39-9

氯诺昔康
Chlortenoxicam
Ro 13-9297

Lornoxicam (Chlortenoxicam) 是高活性 COX-1 和 COX-2 抑制剂，IC50 分别为 5 nM 和 8 nM，是一个新型非甾体抗炎化合物。

生物活性

Lornoxicam (Chlortenoxicam), aCOX-1andCOX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID). Target:COXLornoxicam showed a balanced inhibition of COX-1/-2 exhibiting the lowest IC50 (0.005 microM/0.008 microM) of the large panel of NSAIDs tested. lornoxicam showed a marked inhibition ofIL-6formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta andIL-8was only moderately affected [1]. Lornoxicam is effective in the treatment of patients with activated osteoarthritis; the analgesic and anti-inflammatory effects of lornoxicam are significantly superior to those of rofecoxib without inferiority in tolerability [2]. Lornoxicam was fully effective for prevention of hyperalgesia [3].

IC₅₀& Target^[1]

COX-1

5 nM (IC₅₀, in cells)

COX-2

45 nM (IC₅₀, in cells)

Clinical Trial

分子量

371.82

性状

Solid

Formula

C₁₃H₁₀ClN₃O₄S₂

CAS 号

70374-39-9

中文名称

氯诺昔康

结构分类

Others

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 3.8 mg/mL(10.22 mM;Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.6895 mL	13.4474 mL	26.8947 mL
5 mM	0.5379 mL	2.6895 mL	5.3789 mL
10 mM	0.2689 mL	1.3447 mL	2.6895 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。