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H-D-Ser-OH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
H-D-Ser-OH图片
CAS NO:312-84-5
包装与价格：
包装价格(元)
25g询价
100g询价

H-D-Ser-OH ((R)-Serine) 是一种参与神经胶质-突触相互作用的内源性氨基酸，具有独特的神经递质特征，是 NMDA 谷氨酸受体的有效共激动剂。
Cas No.312-84-5
别名D-丝氨酸; (R)-Serine
化学名(2R)-2-amino-3-hydroxypropanoic acid
Canonical SMILESC(C(C(=O)O)N)O
分子式C3H7NO3
分子量105.09
溶解度PBS (pH 7.2): 5mg/mL
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(R)-Serine, an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. (R)-Serine has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR[3].

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain[4].

References:
[1]. Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.
[2]. MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression Front Psychiatry. 2019 Feb 6;10:25.
[3]. Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.
[4]. Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.

 
 
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