COX-2/5-LOX-IN-3

立即咨询

COX-2/5-LOX-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2481484-51-7

COX-2/5-LOX-IN-3 (compound 5b) 是一种COX-2/5-LOX 的有效双重抑制剂，COX-1、COX-2 和 5-LOX 的IC₅₀值分别为 45.73、5.45 和 4.33 μM。COX-2/5-LOX-IN-3 在炎症疾病研究中具有潜在价值。

生物活性

COX-2/5-LOX-IN-3 (compound 5b) is a potent and dualCOX-2/5-LOXinhibitor withIC₅₀values of 45.73, 5.45 and 4.33 μM forCOX-1,COX-2, and5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases^[1].

IC₅₀& Target^[1]

COX-2

5.45 μM (IC₅₀)

COX-1

45.73 μM (IC₅₀)

5-LOX

4.33 μM (IC₅₀)

体内研究
(In Vivo)

COX-2/5-LOX-IN-3 (compound 5b) (p.o.; male Sprague Dawley rats) shows anti-inflammatory activities in vivo^[1].

Animal Model:	Male Sprague Dawley rats^[1]
Dosage:	2.622 X 10^-5mol/kg
Administration:	Oral administration
Result:	The percentage inhibition of edema (%I) reached 58.77% after 4h.

分子量

361.85

Formula

C₁₇H₁₆ClN₃O₂S

CAS 号

2481484-51-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.