COX-2-IN-26

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COX-2-IN-26

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2413565-19-0

COX-2-IN-26 是一种有效、选择性和口服活性的COX-2抑制剂，COX-1、COX-2、15-LOX 的IC₅₀值为分别为 10.61、0.067、1.96 μM。COX-2-IN-26 显示出抗炎活性。COX-2-IN-26 显示胃肠道安全性。

生物活性

COX-2-IN-26 is a potent, selective and orally activeCOX-2inhibitor withIC₅₀values of 10.61, 0.067, 1.96 μM forCOX-1,COX-2,15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile^[1].

IC₅₀& Target^[1]

COX-2

0.067 μM (IC₅₀)

COX-1

10.61 μM (IC₅₀)

15-LOX

1.96 μM (IC₅₀)

体外研究
(In Vitro)

COX-2-IN-26 (compound 16) shows significant COX-2 selectivity with an SI value of 158.36^[1].

体内研究
(In Vivo)

COX-2-IN-26 (28 μM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 102% and 119% in 4h and 3h, respectively^[1].
. COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats^[1].

分子量

507.65

Formula

C₂₃H₂₁N₇OS₃

CAS 号

2413565-19-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.