COX-2-IN-21

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COX-2-IN-21

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2519631-11-7

COX-2-IN-21 (Compound 5c) 一种具有选择性和口服活性的COX-2抑制剂，IC₅₀为 0.039 μM。COX-2-IN-21 显示出良好的抗炎潜力。

生物活性

COX-2-IN-21 (Compound 5c) is a selective and orally activeCOX-2inhibitor with anIC₅₀of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential^[1].

IC₅₀& Target

COX-2

0.039 μM (IC₅₀)

COX-1

12.4 μM (IC₅₀)

体外研究
(In Vitro)

COX-2-IN-21 (Compound 5c) (50 mg/kg) shows better anti-inflammatory activity and is less ulcerogenic than Celecoxib^[1].
COX-2-IN-21 (50 mg/kg) displays potent inhibitory effect on the production of PGE₂greater than Celecoxib, decreases rat serum concentrations of both TNF-α (% inhibition = 55.349) and IL-6 (% inhibition = 61.561) in a comparable or better activity to Celecoxib^[1].

分子量

422.44

Formula

C₂₁H₂₂N₆O₄

CAS 号

2519631-11-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.