Balanophonin 是一种抗炎和抗癌剂。Balanophonin 通过抑制激活的小胶质细胞诱导的凋亡 (apoptosis) 来抑制小胶质细胞激活和神经退行性变。
| 生物活性 | Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-inducedapoptosis[1]. |
| IC50& Target[1] | |
体外研究
(In Vitro) | Balanophonin (1-10 μM; 24 h) 在 BV2 细胞中降低 Lipopolysaccharides (LPS; HY-D1056) 介导的 TLR4 激活和 NO 生成[1]。
Balanophonin (1-10 μM; 6 h) 降低 LPS 诱导的小胶质细胞中 iNOS 和 COX2 蛋白的表达以及 TNF-α 和 IL-1β 的产生[1]。
Balanophonin (1-10 μM; 30 min) 有效抑制 MAPK 激活[1]。
Balanophonin (1-10 μM; 24 h) 通过调节 N2a 细胞中裂解的 caspase-3 和聚 ADP 核糖聚合酶 (PARP) 的裂解，抑制 LPS 激活的小胶质细胞引起的神经元细胞死亡[1]。
Western Blot Analysis[1] | Cell Line: | LPS-activated BV-2 cells | | Concentration: | 1, 5, and 10 μM | | Incubation Time: | 30 min for MAPKs, 6 h for iNOS and COX2 and 24 h for PGE2, TNF-α and IL-1β | | Result: | Downregulated TLR4. Reduced iNOS and COX2 expression. Significantly reduced the secretion of TNF-α and IL-1β. Decreased the phosphorylation of MAPKs such as pERK, pJNK, and p-p38. |
Western Blot Analysis[1] | Cell Line: | Neuroblastoma N2a cells | | Concentration: | 1, 5, and 10 μM | | Incubation Time: | 24 h | | Result: | Slightly increased Bcl-2. Inhibited caspase-3 activation and PARP cleavage. |
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| 来源 | - Plants
- Balanophoraceae
- Balanophora japonicaMakino
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
