COX-2-IN-23

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COX-2-IN-23

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2417995-08-3

COX-2-IN-23 (compound 9a) 是一种选择性的COX-2抑制剂，COX-2 和 COX-1 的IC₅₀值分别为 0.28 和 20.14 μM。COX-2-IN-23 具有抗炎活性和低致溃疡活性。

生物活性

COX-2-IN-23 (compound 9a) is a selectiveCOX-2inhibitor withIC₅₀values of 0.28 and 20.14 μM forCOX-2andCOX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.

IC₅₀& Target

COX-2

0.28 μM (IC₅₀)

COX-1

20.14 μM (IC₅₀)

体内研究
(In Vivo)

COX-2-IN-23 (compound 9a) (9 mg/kg; a single i.p.; 0-4 hours) exhibits anti-inflammatory activities and lowest incidence of pepticulcer^[1].

Animal Model:	Mature male albino rats^[1]
Dosage:	9 mg/kg
Administration:	Intraperitoneal injection; 0, 1, 2, 3 and 4 hours.
Result:	Had similar ulcerogenic activity to celecoxib.

分子量

495.62

Formula

C₂₄H₂₅N₅O₃S₂

CAS 号

2417995-08-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.