Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent^[1][2]. Floctafenine is an inhibitor ofCOX-1andCOX-2activities in vitro,showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain treatment^[3].

Floctafenine (0.1-100 μM; in the presence of LPS; 24 hours) is slightly more potent 1.5-fold to inhibit in vitro platelet COX-I than monocyte COX-2. The IC₅₀values for platelet COX-I and monocyte COX-2 inhibition are 2.33 μM (95%CI) and 3.47 μM (95%CI), respectively in heparinized whole blood samples^[3].
Floctafenine (0.1-100 μM; in the presence of A23187; 1 hour) does not significantly affect A23187-caused LTB4 generation even up to 100 μM^[3].

Floctafenine (intraperitoneal injection; 50 mg/kg; single dose; 30 minutes prior to p-benzoquinone) has an inhibitory effects on p-benoquinone-induced writhing in rats, inhibition of writhing is 65.98%^[1].

406.36

C₂₀H₁₇F₃N₂O₄

23779-99-9

弗洛非宁；夫洛非宁

Room temperature in continental US; may vary elsewhere.

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